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Research

  1. Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.).
  2. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary
  3. SILIBININ INHIBITS ETHANOL METABOLISM AND ETHANOL-DEPENDENT CELL PROLIFERATION IN AN IN VITRO MODEL OF HEPATOCELLULAR CARCINOMA
  4. Hamid, Kalantari, et. al. “Effects of Silybum Marianum on Patients With Chronic Hepatitis C” Journal of Research in Medical Sciences. March 2011. Pgs 287-290.
  5. Sangmin Kim, et al. “Silibinin Suppresses EGFR Ligand-induced CD44 Expression through Inhibition of EGFR Activity in Breast Cancer Cells” Anticancer Res November 2011 31 (11) 3767-3773
  6. Tyagi, Alpna, et al. “Silibinin Impairs Constitutively Active TGF?-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells” Pharmaceutical Research. September 2008. Pgs 2143-2150
  7. El Kamary, Samer, et al. “A Randomized Controlled Trial to Assess the Safety and Efficacy of Silymarin on Symptoms, Signs and Biomarkers of Acute Hepatitis” Phytomedicine. May 2009. Pgs 391-400.
  8. Naheer, Bhatia, et al. “Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin” Cancer Letters. July 1999. Pgs 77-84.
  9. Davis-Seares, Paula et al. “Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells” Cancer Research. May 2005. Pgs. 4448-4457.
  10. Kumar Das, Subir et. al. “Protective Effects of Silymarin Derivative on Ethanol-Induced Oxidative Stress in liver.” Indian Journal of Biochemistry and Biophysics. July 2006. Pgs 306-311
  11. Ferenci P. et. al. “Randomized Controlled Trial of Silymarin Treatment in Patients with Cirrhosis in Liver” Journal of Hepatology. Pgs 105-113.
  12. Katiyar, SK. “Silymarin and Skin Cancer Prevention: Anti-Inflammatory, Antioxidant, and Immunomodulatory Effects”
  13. Katiyar, SK.  “Protective Effects of Silymarin Against Photocarcinogenesis in a Mouse Skin Model” JNCI J Natl Cancer Inst (1997) 89(8): 556-565 doi:10.1093/jnci/89.8.556
  14. Wellington, Keri, et. al. “Silymarin: A Review of its Clinical Properties in the Management of Hepatic Disorders” Drug Evaluation. Fall 2001. Pgs 465-489.
  15. Zi Xiaolin, et al. “Novel Cancer Chemopreventive Effects of a Flavonoid AntioxidantSilymarin: Inhibition of mRNA Expression of an Endogenous Tumor Promoter TNF?” Biochemical and Biophysical Research Communications. October 1997. Pgs 334-339.
  1. Dihydromyricetin as a novel anti-alcohol intoxication medication
  2. Influence of Hovenia dulcis DHM on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking
  3. Pharmacological potential of ampelopsin (DHM) in Rattan tea
  4. Effects of fruits of Hovenia dulcis (DHM) Thunb on acute alcohol toxicity in mice
  5. Effect of juice and fermented vinegar from Hovenia dulcis peduncles on chronically alcohol-induced liver damage in mice.
  6. Treatment of Chronic Liver Injuries in Mice by Oral Administration of Ethanolic Extract of the Fruit of Hovenia dulcis
  7. Inhibitory effects of hovenia dulcis extract (ampelopsin) on angiogenesis
  8. Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin.
  9. Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide
  10. Dihydromyricetin inhibits cell invasion and down-regulates MMP-2/-9 protein expression levels in human breast cancer cells
  11. Anti-tumor effects of ampelopsin (DHM) on human lung cancer GLC-82 implanted in nude mice
  12. Study on inhibitory effect of ampelopsin (DHM) on melanoma by serologic pharmacological method.
  13. Flavonoid Ampelopsin (DHM) Inhibits the Growth and Metastasis of Prostate Cancer In Vitro and in Mice
  14. Anti-invasive and anti-metastatic effect of ampelopsin on melanoma
  15. Ampelopsin sodium exhibits antitumor effects against bladder carcinoma in orthotopic xenograft models
  16. Zhang YS, Ning ZX, Yang SZ, Wu H. Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata. Yao Xue Xue Bao. 2003 Apr;38(4):241-4.
  17. Yang XM, Wang XH, Chen LF, Wang XQ. Effects of dihydromyricetin on tumor necrosis factor and NF-kappaB p65 of RAU rats. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2612-7

The Great Aussie Hangover Cure provides prophylactic protection against the negative effects of drinking too much alcohol! The Great Aussie Hangover Cure is a potent drinking companion extracted from the St Mary’s Thistle and the Oriental Raisin Tree  that works both by improving the ability of the liver to process alcohol and its toxic metabolite acetaldehyde and by blocking the effect of alcohol on the brain.

And the best part, unlike most pills you buy these days…these one actually F***ing work!
That’s why we want you to try them FREE!

Every 300mg capsule contains 150mg of Pharmaceutical Grade DHM 98% and 150mg of Pharmaceutical Grade Sylimarian 80%.

Milk thistle extract, with its active component silymarin, is nature’s own liver supporter and protector. Already an established herbal treatment for conditions such as alcohol-related liver disease and chronic hepatitis, it has proved itself to optimize the function and maximize the detoxifying and cleansing potential of the liver.

Milk thistle (Silybum marianum) produces small hard fruits (sometimes referred to as seeds) from which highly concentrated extracts in herbal supplements are made today. While milk thistle seeds were used to promote liver health as far back as 2,000 years ago, modern use of the herb began in 1968 with the discovery of the bioflavonoid complex silymarin. Researchers discovered that its health benefits largely reside in this complex and has led to the development of highly concentrated extracts that are standardized to 80% silymarin.

Milk thistle extracts and silymarin exert their benefits in the following ways:

Cell Protection: Directly aids liver cells by binding to the outside of cells and blocking the entrance of certain toxins. In addition, toxins that are already in liver cells are neutralized by silymarin. These actions also help protect against dangerous chemicals, such as carbon tetrachloride, alcohol, acetaminophen, and some commonly prescribed medications.

Boosts Antioxidant Activity: It is particularly useful for increasing production of glutathione—a powerful antioxidant produced by the body, as well as increasing the levels of other antioxidants, such as superoxide dismutase.

Cell Regeneration: Alcohol abuse, chronic hepatitis, and even commonly prescribed drugs , such as cholesterol-lower ing medications and antidepressants, can injure liver cells. Silymarin has the unique ability to help regenerate damaged liver cells.

Anti-fibrotic Actions: Fibrosis is a process that occurs in the liver cells due to inflammation. The most common contributors to this process are alcohol abuse and chronic viral hepatitis (both B and C). By acting as a blocker, silymarin not only helps maintain liver health, but slows the progression of irreversible liver damage, also known as cirrhosis.

Dihydromyricetin is a compound found in hovenia dulcis, which is more commonly known as the Oriental Raisen Tree. It has been used in traditional Chinese Medicine for centuries as a hangover cure and as a method of preventing alcohol intoxication, but has just recently gained recognition outside of Asia.

Recent research has shown that DHM acts as a “sober pill”, if you are drunk and take DHM it will cause you to sober up at a quicker rate and will prevent a hangover the next morning. [1][2][3][4] If you take DHM before drinking alcohol, it will make it much more difficult to become intoxicated. [1][2][3][4] It has also been found to be very good for the liver, and can help mitigate some of the liver damage caused by alcohol. [1][2][3][5][6][7][8][9]

It’s sobriety inducing effects are not instantaneous, however, it simply decreases the time necessary to sober-up. Taking DHM at last call will not sober you up in time to drive home! What it will do is cause you to become fully sober faster than you otherwise would, and will prevent a hangover the next morning.

It really depends on how much you drink! If you are a “light drinker” we recommend taking two capsules after you’ve finished drinking, before bed, to prevent a hangover the next morning. If you are a “pro drinker” or on a binge and expect to drink over 7 drinks you may want to start the night with 3 capsules, and take an additional 2 capsules or so every couple of drink, and then 3 more before going to bed. If you are a heavy drinker and want to protect yourself from liver damage we also suggest you pop a couple of capsules every morning as a liver detox and tonic.

The Great Aussie Hangover Cure is a completely safe supplement. The plants from which it is extracted have been used safely for centuries for its anti-hangover and intoxication reducing effects. Recent study of Silymarin and Dihydromyricetin found them to have no major side effects. [1] TGAHC is an extremely safe supplement, and is well-tolerated by the body.

Unlike many other companies that sell hangover relief products, we aren’t hawking snake oil. The scientific research proves that Silymarin and Dihydromyricetin works, and we go out of our way to acquire and sell only the highest quality product. We’ve sold The Great Aussie Hangover Cure to thousands of happy & regular customers, and we’re confident that once you try it you’ll be blown away!

How confident? If you’re not satisfied with the results you get we will give you a full refund!

Research has shown that Silymarin and Dihydromyricetin  provide the following benefits:

  • Prevents Hangovers
  • Prevents drunkenness, reduces existing intoxication.
  • Reduces symptoms of alcohol withdrawal.
  • Prevents and helps repair liver damage.
  • Can help reduce brain damage due to oxidative stress.

Please see our research section for details.

 

Studies on both Silymarin and Dihydromyricetin found that they causes the liver to metabolize alcohol at a faster rate, and causes your BAC to fall at a faster rate then it otherwise would. That said, there is little information on how much faster your BAC will decrease, but it will not be instantly.

TGAHC in no way causes instant sobriety, so do not think that you’ll be safe to drive just because you took one a little earlier in the night. Never drink and drive!